The World Health Organization estimates that smoking will cause one billion deaths during the 21st century.

Smoking remains one of the leading causes of preventable disease and death worldwide, contributing to cancer, cardiovascular disease, stroke and chronic respiratory disease.

Around 80% of the world's smokers live in low- and middle-income countries (LMIC), where access to effective smoking cessation support and treatment for smoking-related diseases is often limited. As a result, these countries bear a disproportionate share of the global health burden caused by smoking.